You lose between 10%-20% of your power because propane needs much more air/fuel to run, in order to get the power back you'll have to increase your compression with a turbocharger or supercharger. I wouldn't worry about pre-ignition because propane has a pretty high octane rating.
because propane and natural gas has such a high octane rating it will probably never be used as a primary fuel in a diesel engine. (diesel's octane rating is around 25)
my 2 cents
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